Which Trial Model is Right for You?
Compare decentralized, hybrid, and traditional approaches to find the perfect fit for your research goals.
Comprehensive Comparison
See how each model performs across key dimensions of clinical trial execution.
| Feature | Traditional Site-Based | Hybrid Model | Fully Decentralized |
|---|---|---|---|
| Recruitment | |||
Recruitment Speed DCTs can recruit 3x faster by removing geographical barriers. | Slow | Moderate | Fast |
Participant Diversity DCTs enable participation from underrepresented populations. | Limited | Improved | Highest |
Geographic Reach DCTs can recruit from anywhere, not just near research sites. | Site-dependent | Extended | Nationwide/Global |
| Patient Experience | |||
Site Visit Requirements DCTs minimize or eliminate the need for in-person site visits. | Frequent | Reduced | Minimal/None |
Patient Burden DCTs reduce travel time, costs, and disruption to daily life. | High | Moderate | Low |
Retention Rates DCTs typically see 25-30% higher retention rates. | Lower | Improved | Highest |
| Data Collection | |||
Real-time Data Access DCTs provide immediate access to patient-reported data. | Delayed | Partial | Comprehensive |
Data Quality DCTs reduce transcription errors and enable real-time validation. | Variable | Improved | Highest |
Continuous Monitoring DCTs enable ongoing data collection via wearables and apps. | Limited | Partial | Extensive |
| Operations | |||
Site Management DCTs reduce or eliminate site management requirements. | Complex | Moderate | Simplified |
Protocol Flexibility DCTs can adapt more easily to changing requirements. | Rigid | Somewhat Flexible | Highly Flexible |
Cost Efficiency DCTs can reduce costs by 15-30% compared to traditional trials. | Expensive | Moderate | Most Efficient |
| Technology | |||
AI Optimization DCTs leverage AI for recruitment, monitoring, and analysis. | Minimal | Partial | Extensive |
Integration Complexity DCTs require more sophisticated technology integration. | Low | Moderate | Higher |
Technical Support Needs DCTs require more robust patient and site technical support. | Low | Moderate | Higher |
Sample Trial Profiles
Explore which model works best for different types of clinical research.
Traditional Site-Based
Best for trials requiring complex procedures, intensive monitoring, or specialized equipment that cannot be deployed remotely.
Best for:
- Phase I safety studies
- Surgical interventions
- Complex imaging requirements
- Specialized lab work
Hybrid Model
Ideal for studies that benefit from some in-person assessments while leveraging remote capabilities for routine data collection.
Best for:
- Phase II-III with some on-site visits
- Studies with periodic imaging
- Trials with both PROs and clinician assessments
- Studies in semi-rural areas
Fully Decentralized
Perfect for studies focused on patient-reported outcomes, wearable data, or those targeting rare diseases with geographically dispersed populations.
Best for:
- Phase IV post-marketing studies
- Rare disease research
- Long-term observational studies
- PRO-focused research
Mahalo supports all three models with unified technology
Our flexible platform adapts to your specific trial requirements, whether you're running a traditional site-based study, a hybrid approach, or a fully decentralized trial.
Unified Platform
One platform, multiple deployment models, consistent data structure.
Ready to Transform Your Clinical Research?
Book a personalized demo or connect with our team to see how Mahalo Research can support your next study.